It used to be taboo.
Now, cannabis is poised to take 2018 by storm.
  Only a few years ago, marijuana was seen as a ‘’gateway drug’’. 
Flash forward to today: cannabis is a huge business, one that  could be worth $25  billion in the U.S. alone by 2020, and analysts expect demand to  skyrocket as new laws are passed and social attitudes change. 
In the United States, the legal cannabis industry is worth $6.7  billion, according to Bloomberg. A dozen states have passed more relaxed laws  and in October 2017 public support for legalizing marijuana reached an all-time  high of 64 percent.
In Canada alone, cannabis is estimated to become an $8 billion  market with 300,000 people using marijuana for medical purposes today.  When pot is legalized by the Canadian federal government this year, that number  could double virtually overnight…to say nothing of the 5 million Canadians who  use pot recreationally.
Demand could increase dramatically after pot is legalized for  recreational purposes in the coming months.
By 2021, there could be 3.8  million legal users consuming 420,000 kilograms of pot.
While the potential for growth is huge, the legal cannabis  industry is still in its infancy. At the moment, legal growers supply only  60,000 kilograms of Canada’s weed, or 7 percent of anticipated total medical  and recreational demand. 
Only $220 million was invested in cannabis in 2016. Yet that’s a  significant increase from investment in 2013, which was a scant $13 million. In  2018 alone, there has already been over $1 billion raised by publicly traded  cannabis companies in Canada.
It can be a challenge to invest in cannabis. Most publicly-traded  firms are small-caps, and some are downright speculative. The immense  enthusiasm for cannabis in early 2018 has led to fears of a  bubble forming. 
But that doesn’t mean that major opportunities aren’t out there,  waiting to be seized. Marijuana has become one of the most exciting investing  sectors in North America, and that buzz won’t go away any time soon.
Smarter investors can look for ways to profit from the rise in  cannabis without exposing themselves to too much risk. This presents some  unique opportunities to get in on the ground floor, especially when you look at  new and specialized growers and the likelihood that larger firms, particularly  those in the tobacco trade, will get in on the action as well. 
Here’s a look at some companies that are getting into the cannabis  game:
1) Philip Morris (NYSE:PM)
Investors often look to Big Pharma to find solid plays in the  booming cannabis sector, but alternatively, they should be looking at Big  Tobacco.
Back in the 1960s, when social interest in marijuana began to grow,  rumors circulated that Big Tobacco was buying up brand names for marijuana  products. But the government crackdown on drugs put that on the backburner.
Now, Big Tobacco is looking to get back into the marijuana market,  since it’s clear that big money could be at stake. As cigarette smoking declines,  Big Tobacco has started pushing e-cigarettes. Now they could do the same with  marijuana.
Philip Morris is no exception. As its stock declines with news of  falling cigarette sales, the massive tobacco firm can tell  which way the wind is blowing.
Its 2016 investment in  Israel’s Syqe Medical was the 2nd largest deal in the cannabis space  that year. It plans to invest $20  million in Syqe Medical.
The company now owns a  patent for a GMO plant with high terpenes, with application in the medical  marijuana market.
 As Tobacco markets have grown more mature, the company has been  exploring reduced-risk smoking products, with its heated-tobacco iQOS system currently  under consideration by the U.S. Food and Drug Administration as a  “modified risk tobacco product.” 
Philip Morris is playing it safe: it continues to argue that  marijuana is illegal and does not constitute a safe investment. 
  These are quiet moves, but wise  investors know that Big Tobacco will make  a move into marijuana as soon as the waters are right. 
2) Cannabis  Wheaton (TSX-V:CBW; OTC: CBWTF)
Without question, the biggest frontier in the marijuana market is  Canada.
The country is looking at full legalization by late Summer 2018,  which would make it the world’s first federally regulated major marijuana  sector. 
No Canadian cannabis company is growing as quickly as Cannabis  Wheaton. The company’s unique approach to fight the supply deficit takes  a leaf out of Netflix’s book: “streaming weed,” where the company offers  growers capital to build out or expand their cultivation facilities in return  for a minority equity interest and a “stream” of cannabis. 
The company is also “vertically-integrated,” with investments  throughout the cannabis supply chain from “upstream” production to “downstream”  marketing and distribution.
It’s bringing the old Big Oil playbook to the cannabis sector:  cover every part of the chain to reduce costs and maximize profits.
CBW has producers lining up. The company has over 15 partners,  with 17 facilities and a potential 2.0 million effective square feet of  productive acreage. 
In exchange for the capital invested, CBW gets some of the  producer’s shares and a percentage of all of the cannabis produced. 
CBW has established relationships with 39 clinics already and has  access to 30,000 registered medical marijuana patients.
The cannabis market in Canada is expected to explode, what with  legalization just around the corner. Cannabis Wheaton anticipates that demand  will outstrip supply to 2021.
With that  in mind, Cannabis Wheaton is pushing more money into upstream investments. It acquired Dosecann Inc., a dealer  with a 42,000 square foot facility on Prince Edward Island. In late 2017, it  purchased RockGarden, another licensed producer (since renamed  KoLab Inc.). 
  And just in the past few weeks, Cannabis Wheaton picked up Robinson’s Cannabis Inc., a producer  that is close to completing a 27,000 square foot cultivation facility.
  With these new acquisitions and falling production costs, Cannabis Wheaton  expects revenue to significantly increase as their partner’s facilities come  online through 2018 and 2019.
  The  management at Cannabis Wheaton knows the legal marijuana sector better than any  other company out there. CEO Chuck Rifici co-founded Canopy Growth Corp. (formerly  Tweed Marijuana Inc.) which has a current market cap of over $6.0 billion. 
  There  is strong  political support for CBW’s unique business model, which could  prevent a major supply deficit in cannabis once it becomes legal for  recreational use in 2018.
 With  support like this, a strong model and high potential for immense growth once  legalization takes off, Cannabis Wheaton is definitely a cannabis stock to  watch. 
3) Altria Group (NYSE: MO)
This tobacco  giant controls more than half of all cigarette sales in the U.S. and,  like Philip Morris, might be on the verge of entering the marijuana business.
Falling cigarette sales and changing regulation could drive the  company to a rapid change of strategy. 
The way forward could be through vaping, which has seen a  significant increase in popularity in recent years, particularly  among younger users. Since 2016, Altria has invested heavily  in vape technology and continues to watch marijuana legislation very closely. 
Altria, a solid earner with a great dividend, has been able to  keep shareholders happy by raising prices. But this can’t last forever, and  rising competition from vape manufacturers and poor  quarterly performance will soon force a change in the company’s  strategy.
Altria is the best-equipped  company to take advantage of marijuana’s increasing legality. It owns  many excellent cigarette brands and has massive financial resources. Right now  it spends almost nothing on advertising, since most tobacco ads are prohibited. 
It’s net revenue ($14.2 billion in 2016) and $200 capex put it in  a good position to enter the cannabis sector through MA acquisitions.
Altria is bound to turn to cannabis, and many  analysts predict that it will, along with other Big Tobacco  firms like Philip Morris, embrace the new drug sooner rather than later.
4) Insys Therapeutics (Nasdaq: INSY)
Along with Big Tobacco, the industry which is sure to embrace  cannabis is Big Pharma.
Weed’s breakthrough came in the medical sector, as marijuana  emerged as a popular and effective medical treatment. Nowadays, medical  marijuana is prescribed for a wide range of ailments such as pain, depression,  anxiety and glaucoma.
While not a marijuana stock per se, Insys Therapeutics is on the  cutting edge of the emerging trends in medical marijuana research and  development. 
The company has two drugs approved by the U.S. FDA, named Subsys  and Syndros. Syndros uses tetrahydrocannabinol  (THC), a compound found in marijuana, to treat patients suffering from seizures. 
With the DEA determining synthetic  THC to be safer and more manageable than cannabis, which remains illegal on the  federal level, Syndros could quickly gain traction in U.S. markets.  
The company has been quite successful marketing these  products, and looks set to invest some of its significant cash flow (it had  $236.7 million in-hand at the end of 2016) into new research and development of  cannabis-related drugs.
The company has faced some severe headwinds in 2018, as its  stock tanked in March. The reason? Growing concerns over the national opioid  epidemic in the United States.
Nevertheless, Syndros sales got off  to a great start in 2017 and the drug should prove a strong earner for Insys  this year
Right now, the stock is depressed.  Investors should snap it up before it makes a comeback later this year.
5) GW Pharmaceuticals (Nasdaq: GWPH)
With its $3 billion valuation and a strong track record, GW  Pharmaceuticals is probably the biggest firm entering the cannabis space.
  GW has developed a number of new products in recent years, including drugs  aimed at epilepsy, infantile spasms, autism and schizophrenia.
 But the company’s new drug Epidiolex is about the make history:  the experimental  product, used to treat childhood epilepsy, could be the first  marijuana-based epilepsy drug to get federal approval in the  United States.
The FDA panel ruled unanimously that the drug’s benefits outweigh  the potential risks. The decision would be a game  changer and could open the floodgates for dozens of other marijuana-based  treatments to receive federal approval.
The market for the drug might appear small (there are only 20,000  children afflicted with epilepsy), but nationwide more than 2.4 million  Americans suffer from the disease. GW could  earn $500 million from sales of the drug. And that’s just the beginning; other  marijuana-based products could tap into much larger markets. 
The company’s fundamentals are  strong, bolstered by its strong presence in the UK, where  it’s based.
The company plans to invest £50  million and hire 70 new staff for its Britain-based facilities. 
The decision for Epidiolex  could mark a revolution in medical marijuana treatments. And GW Pharma is  poised to take full advantage.
Other companies to keep a close eye on in the space:
    Aphria (TSX:APH) is a Canada-based cannabis  company which focuses on the production, sales, and distribution of legal  marijuana. The company’s business model focuses primarily on online sales,  which is perfect for its patients. A simple point and click and the medication  will arrive at the patient’s in no time.
  Aphria’s products are developed to treat to a variety of different  patients and symptoms. The company offers several smoke free medications for  those who are unable to consume the products in that manner. Aphria also  produces low-THC products for patients who are more sensitive to marijuana’s  psychoactive properties.
  Aphria’s large market appeal make the company an ideal choice for  investors, as the company is sure to retain, as well as grow their customer  base over time.
THC Biomed International Ltd (CSE:THC)  operates as a licensed producer under  Canada's Marihuana for Medical Purposes Regulations. It is also engaged in the  research & development of the products and services to medical marijuana. 
  THC’s share price bounced back in November after the company announced the  creation of THC2Go dispensaries – a fully owned subsidiary, focused at the  retail cannabis products – in the province of Manitoba.
Harvest One Cannabis (TSXV:HVT): Harvest One Cannabis Inc,  formerly Harvest One Capital Inc, is a Canadian company focused on servicing both  recreational and medicinal markets.
  Harvest One recently raised $25 million in equity financing and $9 million will  be used to finance Phase 1 production capacity expansion at United Greeneries’  Duncan Facility. 
  Harvest One has seen its share price increase in September and we think the  company is well-positioned to take advantage of Canada’s looming legalization  of recreational marijuana.
Aphria Inc (TSX:APH): Aphria Inc is engaged in  the production and selling of medicinal marijuana, and while the stock has  trended downward since April, the constant profits here suggest there is a lot  of upside. The recent pro-marijuana legislation from the Canadian government is  sure to boost companies with the reputation of Aphria Inc.
  Aphria’s $137 million expansion project is well underway to ramp up output to  70,000 kg. If Aphria successfully ramps up production, we believe its share  price could go much higher. 
Beleave (CSE:BE): Beleave is a biotech company focused on the production of medical marijuana in Canada.  Its wholly-owned subsidiary, First Access, applied for a pre-license inspection  in March 2017.
Beleave became Cannabis Wheaton’s fifth  production partner in May and the parties will work cooperatively to identify  an appropriate second site to be acquired and developed by a newly formed  special purpose subsidiary of Beleave ("NewCo"). The proposed second  site is expected to be located in Ontario and will be designed to accommodate  an estimated 200,000 square feet of cultivation space.
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    FORWARD-LOOKING STATEMENT. Statements in this communication which are not purely historical are  forward-looking statements and include statements regarding beliefs, plans,  intent, predictions or other statements of future tense. Forward looking  statements in this article include: that the Canadian government will fully  legalize and regulate cannabis this year; that the US medical and recreational  markets combined will be worth $25 billion in gross sales in the year after  legalization; that by  2021, there could  be 3.8 million legal users consuming 420,000 kilograms of  pot in Canada;   that Cannabis Wheaton Income  Corp. (“Cannabis Wheaton”) can raise funds and partner quickly with new  firms looking to get into the Cannabis industry; Cannabis Wheaton’s revenue  will significantly increase as their partner’s facilities come online through  2018 and 2019; that there will likely be a supply shortage; that, if cannabis  markets open up in other industrialized countries, the global cannabis market  could expand exponentially; that Cannabis Wheaton may be able to help supply  cannabis to markets outside Canada; that producers will need to obtain  additional financing from companies like Cannabis Wheaton; that Canadian sales  of cannabis could reach $8 billion next year; that Cannabis Wheaton could  become a future cannabis “multi-national”; that Cannabis Wheaton can reach  EBITDA margins of 50%; and that the cannabis market in Canada could reach $30  billion by 2024 and in North America reach $24.5 billion by 2021.  Forward-looking information is based on the opinions and estimates of Cannabis  Wheaton at the date the information is made, and is subject to a variety of  risks and uncertainties and other factors that could cause actual events or  results to differ materially from those projected in the forward-looking  information.  Forward looking statements  involve known and unknown risks and uncertainties which may not prove to be  accurate. Actual results and outcomes may differ materially from what is  expressed or forecasted in these forward-looking statements. Matters that may  affect the outcome of these forward looking statements include: that Cannabis  may not be legalized on the timeline as expected or at all; that markets may  not materialize as expected; that cannabis may not turn out to have as large a  market as thought or be as lucrative as thought as a result of competition or  other factors; that Cannabis Wheaton may not be as able to diversify or scale  up  as thought because of potential lack  of capital, lack of facilities, regulatory compliance requirements in Canada or  outside of Canada or lack of suitable employees, partners or suppliers; that  Cannabis Wheaton may not be able to raise funds and offer better conditions to  potential partners than competitors in the cannabis industry; that partners of  Cannabis Wheaton may not be granted licenses or additional capacity under  existing or newly applied for licenses for them to grow for the cannabis  market; that foreign governments may not allow Cannabis Wheaton to operate in  their countries; that actual operating performance of the facilities affiliated  with Cannabis Wheaton do not meet expectations; that competition quickly  develops; that Cannabis Wheaton may not be able to retain key employees,  partners and suppliers; costs may be higher than expected and profits therefore  lower; competitors may capture most or all of the increased market demand; and  other risks affecting the Company in particular and the cannabis industry  generally, including without limitation risks related to most agricultural  crops, including crop failure. The forward-looking statements in this document  are made as of the date hereof and the Company disclaims any intent or  obligation to update such forward-looking statements except as required by  applicable securities laws.
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