Pfizer Inc’s (NYSE:PFE) shares moved slightly higher Monday, on word from Fox news its COVID-19 vaccine on Thursday. Pfizer also applied for emergency approval of its vaccine in India.
The drug maker also announced today announced safety and clinical response results from the ongoing Phase 1 study (NCT03269136) for PF-06863135, an investigational B-cell maturation antigen (BCMA) CD3-targeted bispecific antibody.
Data from 30 patients with relapsed or refractory multiple myeloma showed manageable safety across all subcutaneous dose levels with no dose-limiting toxicities observed, and 83% of patients achieved a clinical response at the highest dose level. The results will be presented today at the Virtual American Society of Hematology (ASH) Annual Meeting and Exposition.
"Despite treatment advances, multiple myeloma remains incurable and there is a substantial need for breakthroughs for patients," said Senior Vice President Jeff Settleman,
"The very high response rate observed with PF-06863135, coupled with manageable safety and the convenience of subcutaneous administration, underscores the potential impact this medicine may have for people living with this devastating disease. These findings support continued development of PF-06863135 for people with multiple myeloma, both as monotherapy and in combination with standard or novel therapies."
PF-06863135 is a bispecific antibody designed to bind to BCMA which is highly expressed on the surface of multiple myeloma cells, and the CD3 receptor found on the surface of cancer-fighting T cells, bridging them together to activate an immune response.
PFE shares began trading Monday up 22 cents to $40.56.
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