The world may be a step closer to successfully treating obesity with psilocybin. That's because psilocybin activates serotonin receptors, or "nature's own appetite suppressant," as noted by Psychology Today. "This powerful brain chemical curbs cravings and shuts off appetite. It makes you feel satisfied even if your stomach is not full. The result is eating less and losing weight." Even better, positive study results on obesity from NeonMind Biosciences (CSE: NEON) (OTC: NMDBF) show “psilocybin's ability to modulate weight gain, which is absolutely critical for any drug candidate targeting obesity and weight loss,” said Robert Tessarolo, President & CEO of NeonMind. “In two separate rodent studies, we have shown that psilocybin has efficacy in modulating weight in both obese and normal subjects.” Not only could that be game-changing news for NEON, but for other psychedelic companies, such as COMPASS Pathways (NASDAQ: CMPS), Cybin Inc. (NEO: CYBN) (NYSE: CYBN), Field Trip Health Ltd. (TSX: FTRP) (NASDAQ: FTRP), and Mind Medicine Inc. (NASDAQ: MNMD) (NEO: MMED).
NeonMind Announces Positive Preclinical Results Demonstrating the Efficacy of Psilocybin in Reducing Weight Gain in Obese Animal Subjects
NeonMind Biosciences, an integrated drug development and wellness company focused on bringing innovative psychedelic-based treatments to people suffering from obesity and mental health disorders, announced today it has released preclinical data demonstrating the efficacy of psilocybin in reducing weight gain in obese subjects. In previous preclinical studies, NeonMind has shown efficacy in reducing weight gain in healthy subjects with normal weight. This latest study suggests a broader therapeutic potential of psilocybin in weight management and supports the current development track of NeonMind’s drug candidates.
The data from NeonMind’s preclinical models revealed a novel finding for its drug candidates: the ability to target visceral fat. Increased visceral fat is linked to poorer cardiometabolic health and reduction in this type of fat is important in weight loss and better overall health outcomes.
Additional findings from the preclinical models in obese subjects include:
- Statistical significance compared to the control group for both absolute and relative weight gain;
- Efficacy seen within days of administration;
- Reduced food consumption compared to control group;
- No safety signals.
The positive results further reinforce the drug development opportunity of NeonMind’s two lead psilocybin-based drug candidates targeting obesity. Moreover, the novel findings provide opportunities to enhance their commercial profiles. These candidates include NEO-001, which employs psilocybin as an agonist at the serotonin 5- HT2A receptor, and NEO-002, which utilizes low-dose psilocybin as an agonist at the 5-HT2C receptor, which controls appetite.
“These latest findings show psilocybin's ability to modulate weight gain, which is absolutely critical for any drug candidate targeting obesity and weight loss,” said Robert Tessarolo, President & CEO of NeonMind. “In two separate rodent studies, we have shown that psilocybin has efficacy in modulating weight in both obese and normal subjects. This is important given visceral fat is associated with increased comorbidities and poorer health outcomes. These findings show promise for the future development of psilocybin-based treatments for obesity, which may also lead to improved cardiovascular and metabolic health.”
Dr. Alasdair Barr, primary investigator of NeonMind’s preclinical study, commented, “These preclinical studies are bringing to light novel findings in an under-researched psychedelic modality: psilocybin-based weight management. We were able to explore key mechanisms that drive obese behavior and have come away with further evidence that psilocybin could potentially lead to a reduction in weight gain in various patient sub-types.”
The manuscript has been submitted to a leading industry peer-reviewed journal for publication.
Other related developments from around the markets include:
COMPASS Pathways, a mental health care company dedicated to accelerating patient access to evidence-based innovation in mental health, and Sermo, a global leader in physician insights, today announced findings from a survey of Sermo physician members that showed two thirds (66%) of doctors surveyed believe psilocybin therapy has potential therapeutic benefit for patients with treatment-resistant depression (TRD). More than 320 million people globally suffer with major depressive disorder (MDD)i, the leading cause of disability worldwide and one of the fastest growing mental health illnesses. About a third of these patients – 100 million people – aren’t helped by existing therapies and suffer with TRD.
Cybin Inc., a biopharmaceutical company focused on progressing "Psychedelics to Therapeutics™" is pleased to announce that Doug Drysdale, Cybin’s Chief Executive Officer, will present at the 2022 Virtual Growth Conference, presented by Maxim Group LLC and hosted by M-Vest, taking place March 28th - 30th from 9:00 a.m. - 5:00 p.m. ET.
Field Trip Health Ltd., a global leader in the development and delivery of psychedelic-assisted psychotherapy, announced a strategic partnership with Cerebral, the fastest growing online mental health platform. The companies are launching a partnership where Cerebral clinicians can refer qualified clients to Field Trip Health's ketamine assisted therapy, while Field Trip will connect potential clients seeking general psychiatry and teletherapy services to Cerebral. This end-to-end solution will provide personalized treatment solutions for those seeking to improve their mental health.
Mind Medicine, a clinical stage biopharmaceutical company developing novel products to treat brain health disorders, announced that it will host its earnings call on Monday, March 28, 2022, at 8:30 a.m. EDT to discuss its financial results for the full year ended December 31, 2021 and provide a business update.
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