The trade deficit south of the border grew by 10% in May as exports fell while imports, particularly from China, rose.
Figures released Wednesday by the U.S. Commerce Department said the trade deficit rose to $41.1 billion in May compared with $37.4 billion in April.
The department said exports waned by 0.2%, while imports grew by 1.6%.
The U.S. consistently runs a trade imbalance, importing more goods than it sells overseas, but as the dollar has strengthened, this gap has become more pronounced.
The deficit is particularly pronounced with China, where the margin increased by 19.4% to $29 billion U.S. - the largest difference since November 2015.
The trade gap with the European Union also widened by 13.5%.
Industrial supplies and consumer goods were the leading imports for the U.S., while exports increased in the food and beverage sector.
Even so, the figure is only slightly higher than the 2016 first-quarter average of $40.6 billion U.S.
