Omeros Corporation (NASDAQ: OMER) rose after the company Monday released additional data Monday from the company’s OMS721 clinical trial in renal disease.
The company, based in Seattle, reported data from study patients with immunoglobulin A (IgA) nephropathy, a progressively worsening kidney disease and the most common glomerulonephritis worldwide, responsible for 10% of all people on dialysis globally.
Patients in this cohort had IgA nephropathy with high risk of progression but none received corticosteroid treatment immediately prior to or during the study – different than the cohort reported last year in which all patients initiated the study while on steroid therapy.
OMS721 is Omeros’ lead human monoclonal antibody targeting mannan-binding lectin-associated serine protease-2 (MASP-2), the effector enzyme of the complement system’s lectin pathway.
In addition to an ongoing Phase 3 clinical trial in IgA nephropathy, OMS721 is in Phase 3 clinical programs for hematopoietic stem cell-associated thrombotic microangiopathy (HSCT-TMA) and for atypical hemolytic uremic syndrome.
"We now have results of treatment with OMS721 in IgA nephropathy patients both with and without concomitant steroid therapy," stated Jonathan Barratt, Professor of Renal Medicine at the University of Leicester and Honorary Consultant Nephrologist at Leicester General Hospital.
"In contrast to the previously reported cohort who were enrolled while on steroid therapy, the patients in this study were steroid-free, and yet the magnitude of proteinuria reduction across both groups is consistent and likely to indicate a significant renoprotective effect of OMS721 in IgAN, with a legacy effect again seen for months beyond cessation of OMS721 treatment."
Shares galloped $1.37, or 9.8%, to $15.33
